Organocatalytic asymmetric Michael addition of unprotected 3-substituted oxindoles to 1,4-naphthoquinone

نویسندگان

  • Jin-Sheng Yu
  • Feng Zhou
  • Yun-Lin Liu
  • Jian Zhou
چکیده

We reported the first example of organocatalytic Michael addition of unprotected 3-prochiral oxindoles 1 to 1,4-naphthoquinone. Quinidine derivative (DHQD)(2)PYR was found to be able to catalyze this reaction in up to 83% ee, with moderate to excellent yields. This method could be used for the synthesis of enantioenriched 3,3-diaryloxindoles, and the catalytic synthesis of which was unprecedented.

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2012